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PD 158780

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CAS:171179-06-9Formula:C14H12BrN5MW:330.2Appearance:YellowSolidPurity:95%

商品详情参考文献相关资料

A potent inhibitor of the EGFR tyrosine kinase activity (IC=8pM). Also inhibits heregulin-stimulated autophosphorylation in SK-BR-3 (IC=49nM)and MDA-MB-453 (IC=52 nM)breast carcinomas.

Additional Information

Synonyms	4-[(3-Bromophenyl)amino]-6-(methylamino)-pyrido[3,4-d]pyridimine
Product #	P-1649
CAS #	171179-06-9
Chemical Name	4-[(3-Bromophenyl)amino]-6-(methylamino)-pyrido[3,4-d]pyridimine
Formula	C₁₄H₁₂BrN₅
MW	330.2
Appearance	Yellow Solid
Purity	95%
Solubility	Soluble in DMSO
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Inhibits heregulin-stimulated autophosphorylation in SK-BR-3 and MDA-MB-453 in breast carcinomas.

Additional Information

MDL Number	MFCD00942160
ChemACX	X1535395-4
InChI	InChI=1S/C14H12BrN5/c1-16-13-6-11-12(7-17-13)18-8-19-14(11)20-10-4-2-3-9(15)5-10/h2-8H,1H3,(H,16,17)(H,18,19,20)
SMILES	CNc1cc2c(cn1)ncnc2Nc3cccc(c3)Br

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