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HLCL-61,PRMT5Inhibitor M60320-2s|产品详情|进口橙子视频旧款采购网




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    上海橙子视频app安卓下载生物科技公司
    Tel:400-968-7988    021-33779008
    HLCL-61,PRMT5Inhibitor
    品牌:Xcessbio
    货号:M60320-2s
    规格:2 mg solid
    货期:

    HLCL-61,PRMT5Inhibitor

    商品详情 参考文献 相关资料
    Product Information
    Molecular Weight: 380.91
    Formula: C23H24N2O.HCl
    Purity: ≥98%
    CAS#: 1158279-20-9
    Solubility: DMSO and EtOH up to 100 mM
    Chemical Name: 1-(9-ethyl-9H-carbazol-3-yl)-N-(2-methoxybenzyl)methanamine hydrochloride
    Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

    Biological Activity:

    HLCL-61 is a potent and selective Protein arginine methyltransferase-5 (PRMT5) Inhibitor. It shows no inhibitory activity against the type I (PRMT1 and PRMT4) and type II (PRMT7) PRMT family members. HLCL-61 shows effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples.Treatment of AML cell lines (MV4-11 and THP-1) and primary blasts with HLCL-61 also results in a decrease of cell viability. HLCL-61 is also effective in promoting apoptosis in MV4-11 and THP-1 cells after 48 h.

    How to Use:


    In vitro: HLCL-61 was used at 25-50 µM final concentration in various in vitro assays.
    In vivo:
    n/a

    Reference:

    • 1. Tarighat SS, et al. The dual epigenetic role of PRMT5 in acute myeloid leukemia: gene activation and repression via histone arginine methylation. (2016) Leukemia. 30(4):789-99. 

         
          

    Products are for research use only. Not for human use.


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