PF-CBP1，CBP/p300BromodomainInhibitor M60313-2s|产品详情|进口橙子视频旧款采购网

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PF-CBP1，CBP/p300BromodomainInhibitor

品牌：Xcessbio

货号：M60313-2s

规格：2 mg solid

货期：

应用：

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PF-CBP1，CBP/p300BromodomainInhibitor

商品详情参考文献相关资料

Product Information

Molecular Weight:	488.62
Formula:	C₂₉H₃₆N₄O₃
Purity:	≥98%
CAS#:	n/a
Solubility:	DMSO up to 100 mM; EtOH up to 100 mM
Chemical Name:	4-(2-(5-(3,5-dimethylisoxazol-4-yl)-2-(4-propoxyphenethyl)-1H-benzo[d]imidazol-1-yl)ethyl)morpholine
Storage:	Powder: 4^oC 1 year. DMSO: 4^oC 3 month; -20^oC 1 year.

Biological Activity:

PF-CBP1 is a potent and selective CBP/p300 bromodomain inhibitor (IC50 ~125 nM for CBP and 363 nM for p300). It has >100-fold selectivity for CBP over BRD4, and shows selectivity over a panel of other bromodomains. PF-CBP1 reduces LPS-induced IL-1β, IL-6 and IFN-β expression in macrophages in vitro. It can also downregulate RGS4 expression in primary cortical neurons in vitro.

How to Use:

In vitro: PF-CBP1 was used at 10 µM final concentration in various assays.
In vivo: n/a

Reference:

1. Chekler EL, et al. Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities. (2015) Chem Biol. 22(12):1588-96.

Products are for research use only. Not for human use.

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