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PF-CBP1,CBP/p300BromodomainInhibitor M60313-2s|产品详情|进口橙子视频旧款采购网




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    上海橙子视频app安卓下载生物科技公司
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    PF-CBP1,CBP/p300BromodomainInhibitor
    品牌:Xcessbio
    货号:M60313-2s
    规格:2 mg solid
    货期:

    PF-CBP1,CBP/p300BromodomainInhibitor

    商品详情 参考文献 相关资料
    Product Information
    Molecular Weight: 488.62
    Formula: C29H36N4O3
    Purity: ≥98%
    CAS#: n/a
    Solubility: DMSO up to 100 mM; EtOH up to 100 mM
    Chemical Name: 4-(2-(5-(3,5-dimethylisoxazol-4-yl)-2-(4-propoxyphenethyl)-1H-benzo[d]imidazol-1-yl)ethyl)morpholine
    Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

    Biological Activity:

    PF-CBP1 is a potent and selective CBP/p300 bromodomain inhibitor (IC50 ~125 nM for CBP and 363 nM for p300). It has >100-fold selectivity for CBP over BRD4, and shows selectivity over a panel of other bromodomains. PF-CBP1 reduces LPS-induced IL-1β, IL-6 and IFN-β expression in macrophages in vitro. It can also downregulate RGS4 expression in primary cortical neurons in vitro.

    How to Use:

    In vitro:
    PF-CBP1 was used at 10 µM final concentration in various assays.
    In vivo:
    n/a

    Reference:


    1. 1. Chekler EL, et al. Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities. (2015) Chem Biol. 22(12):1588-96. 



          
        

      
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