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Biological Activity:

PD-1/PD-L1 inhibitor C1 is a potent and selective small molecule inhibitor of the PD-1/PD-L1 protein/protein interactions with IC50 < 100 nM (PD-1/PD-L1 Homogenous Time-Resolved Fluorescence (HTRF) binding assay). It may potentially be useful in the treatment of cancer as well as infectious diseases such as hepatitis C. The programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) interaction plays a dominant role in the suppression of T cell responses, especially in a tumor microenvironment, protecting tumor cells from lysis.

How to Use:

In vitro: PD-1/PD-L1 Inhibitor C1 was used at 10 µM final concentration in various assays.
In vivo: n/a

Reference:

1. 1. Chupak, L.S. and Zheng, X. Compounds useful as immunomodulators. WO 2015/034820 (2015).