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PFI-2,SETD7HistoneLysineMethyltransferaseInhibitor M60182-2s|产品详情|进口橙子视频旧款采购网




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    上海橙子视频app安卓下载生物科技公司
    Tel:400-968-7988    021-33779008
    PFI-2,SETD7HistoneLysineMethyltransferaseInhibitor
    品牌：Xcessbio
    货号：M60182-2s
    规格：2 mg solid
    货期：

    PFI-2,SETD7HistoneLysineMethyltransferaseInhibitor
    商品详情 参考文献 相关资料
    Product Information
    Molecular Weight: 499.52
    Formula: C23H25F4N3O3S
    Purity: ≥98%
    CAS#: 1627676-59-8
    Solubility: DMSO up to 100 mM
    Chemical Name: (R)-8-fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide
    Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

    Biological Activity:
    PFI-2 is a novel potent and selective SETD7 histone lysine methyltransferase inhibitor with IC50 ~2 nM. It has > 100-fold selectivity over other methyltransferases and other non-epigenetic targets. PFI-2 has been shown to bind to SETD7 by ITC (Kd=18nM), and biotinylated PFI-2 interacts with SETD7 in pull-down studies.


    How to Use:

    • In vitro: PFI-2 was used at 1 µM in vitro.
    • In vivo: n/a


    Reference:

    1. 1. http://www.thesgc.org/chemical-probes/epigenetics



    Products are for research use only. Not for human use.

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