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Biological Activity:

Bromosporine is a broad spectrum inhibitor for bromodomains with IC₅₀ of 0.41 μM, 0.29 μM, 0.122 μM and 0.017 μM for BRD2, BRD4, BRD9 and CECR2, respectively. In cell-based assays, Bromosporine (1 µM) accelerates FRAP recovery of BRD4 and CREBBP, while shows no activities against TIF1α, BAZ2A, and SMARCA2 (at 10 µM). Bromosporine shows moderate cytotoxicity in HeLa cells at 18 µM. It is a very useful chemical probe for bromodomain functional assays. 

How to Use:

In vitro:  Bromosporine was used at 1 µM final concentration in vitro and in cellular assays.

In vivo: n/a

Reference: