LMK235,HDAC4andHDAC5Inhibitor M60145-2s|产品详情|进口橙子视频旧款采购网

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LMK235,HDAC4andHDAC5Inhibitor

品牌：Xcessbio

货号：M60145-2s

规格：2mg solid

货期：

应用：

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LMK235,HDAC4andHDAC5Inhibitor

商品详情参考文献相关资料

Product Information

Molecular Weight:	294.35
Formula:	C₁₅H₂₂N₂O₄
Purity:	≥98%
CAS#:	1418033-25-6
Solubility:	DMSO up to 100 mM
Chemical Name:	N-((6-(hydroxyamino)-6-oxohexyl)oxy)-3,5-dimethylbenzamide
Storage:	Powder: 4^oC 1 year. DMSO: 4^oC 3 month; -20^oC 1 year.

Biological Activity:

LMK235 is a potent and selective histone deacetylase HDAC4 and HDAC5 inhibitor (IC₅₀ ~11.9 nM and 4.22 nM respectively). It also has inhibitory activities against HDAC 6, 1, 11, 2, and 8 with IC₅₀for 55.7, 320, 852, 881, and 1278 nM, respectively. LMK235 exhibits cytotoxity against chemo-resistant cancer cell lines in human ovarian cancer cell lines A2780 and cisplatin resistant A2780CisR (IC₅₀ ~0.49 and 0.32 μM respectively).

How to Use:

In vitro: LMK235 was used at 1 µM final concentration in vitro and in cellular assays.
In vivo: n/a

Reference:

1. Marek L, et al. Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells. (2013) J Med Chem. 56(2):427-36.

Products are for research use only. Not for human use.

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