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SGC707,AllostericPRMT3Inhibitor M60243-2s|产品详情|进口橙子视频旧款采购网




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    上海橙子视频app安卓下载生物科技公司
    Tel:400-968-7988    021-33779008
    SGC707,AllostericPRMT3Inhibitor
    品牌:Xcessbio
    货号:M60243-2s
    规格:2 mg solid
    货期:

    SGC707,AllostericPRMT3Inhibitor

    商品详情 参考文献 相关资料
    Product Information
    Molecular Weight: 298.34
    Formula: C16H18N4O2
    Purity: ≥98%
    CAS#: n/a
    Solubility: DMSO up to 100 mM
    Chemical Name: 1-(isoquinolin-6-yl)-3-(2-oxo-2-(pyrrolidin-1-yl)ethyl)urea
    Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

    Biological Activity:

    SGC707 is a potent, selective and cell permeable allosteric protein arginine methyltransferase 3 (PRMT3) inhibitor with IC50 ~ 31 nM. It has >100-fold selectivity against 31 other methyltransferases and 250 other non-epigenetic targets. SGC707 engages PRMT3 and potently inhibits its methyltransferase activity in cells. It is also bioavailable and suitable for animal studies. This well-characterized chemical probe is an excellent tool to further study the role of PRMT3 in health and disease.

    How to Use:

    In vitro: SGC707 was used at 5-10 µM final concentration in various in vitro assays.
    In vivo: n/a

    Reference:

    • 1. Kaniskan HÜ, et al. A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3). (2015) Angew Chem Int Ed Engl. In press. 

        
      

    Products are for research use only. Not for human use.

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