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 PFI-4,BRPF1BromodomainInhibitor M60264-2s|产品详情|进口橙子视频旧款采购网




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    PFI-4,BRPF1BromodomainInhibitor
    品牌：Xcessbio
    货号：M60264-2s
    规格：2 mg solid
    货期：

    PFI-4,BRPF1BromodomainInhibitor
    商品详情 参考文献 相关资料
    Product Information
    Molecular Weight: 380.44
    Formula: C21H24N4O3
    Purity: ≥98%
    CAS#: 900305-37-5
    Solubility: DMSO up to 50 mM, EtOH up to 10 mM
    Chemical Name: N-(1,3-dimethyl-2-oxo-6-(pyrrolidin-1-yl)-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-2-methoxybenzamide
    Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

    Biological Activity:

    PFI-4 is a potent, selective and cell permeable BRPF1 bromodomain inhibitor. It binds to BRPF1B with a Kd of 13 nM (ITC). It has general >100-fold selectivity against other bromodomains including BRPF2, BRPF3 and BRD4. It reduces recovery time in triple BRD cell construct in FRAP and is potent in cells with IC50 250 nM, while showing no effect on BRPF1A.

    How to Use:

    In vitro: PFI-4 was used at 5-10 µM final concentration in various in vitro assays.
    In vivo: n/a

    Reference:

    • 1. http://www.thesgc.org/chemical-probes/PFI-4


     
         

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