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Alt. Names

EC 3.5.1.-; hSIR2; hSIRT1; NAD-dependent deacetylase sirtuin 1; SIR1; SIR2-like protein 1; SIR2L1; sirtuin 1

Specificity:

SirT1 Antibody detects endogenous levels of total SirT1.

Immunogen:

A synthesized peptide derived from human SirT1

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C. Stable for 12 months from date of receipt.

Western blot analysis of SirT1 expression in K562 whole cell lysates. The lane on the left is treated with the antigen-specific peptide.

Background:

Silent information regulator 1 (SIRT1), is a member of the sirtuin family of proteins, homologs of the Yeast Sir2 protein. Yeast SIRT1 is a nuclear protein that regulates epigenetic gene silencing and suppresses recombination of rDNA. Sirt-1 is defined as a nuclear protein involved in the molecular mechanisms of inflammation and neurodegeneration through the de-acetylation of many different substrates even if experimental data in mouse suggest both its cytoplasmatic presence and nucleo-cytoplasmic shuttling upon oxidative stress (1). Sirt-1 plays important functional roles in many biological processes causing various modifications of histone/protein acetylation status by several class I and II histone deacetylase (HDAC) inhibitors (2).

Please refer PDF file for Western, Immunofluorescence analysis,  Chromatin immunoprecipitation analysis or other QC data.  

• Autiero I., Costantini S., Colonna G. (2009). Human sirt-1: molecular modeling and structure-function relationships of an unordered protein. PLoS ONE 4, 12.10.1371
• Kyrylenko S., Kyrylenko O., Suuronen T., Salminen A. (2003). Differential regulation of the Sir2 histone deacetylase gene family by inhibitors of class I and II histone deacetylases. Cell. Mol. Life Sci. 60, 1990–1997.10.1007