Daidzein-2c,OsteogenicModulator M60158-2s|产品详情|进口橙子视频旧款采购网

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Daidzein-2c,OsteogenicModulator

品牌：Xcessbio

货号：M60158-2s

规格：2mg solid

货期：

应用：

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Daidzein-2c,OsteogenicModulator

商品详情参考文献相关资料

Product Information

Molecular Weight:	296.32
Formula:	C₁₈H₁₆O₄
Purity:	≥98%
CAS#:	97846-18-9
Solubility:	DMSO up to 100 mM
Chemical Name:	3-(4-hydroxyphenyl)-7-isopropoxy-4H-chromen-4-one
Storage:	Powder: 4^oC 1 year. DMSO: 4^oC 3 month; -20^oC 1 year.

Biological Activity:

Daidzein-2c is a potent synthetic daidzein analog, has osteogenic induction potentials on human Mesenchymal Stem Cells (MSC). Human bone marrow derived mesenchymal stem cells from three different donors were treated with Daidzein-2c and shown to exhibit enhanced osteogenesis when compared to daidzein or estrogen treatment. The enhanced osteogenic induction by Daidzein-2c resulted in increased osterix (Sp7), alkaline phosphatase (ALP), osteopontin (OPN), and insulin-like growth factor 1 (IGF-1), which are osteogenic factors that regulate the maturation of osteogenic progenitor cells into more differentiated osteoblast cells. It serves as a useful chemical tool to further validate and develop novel treatments of osteoporosis via promoting bone formation.

How to Use:

In vitro: Daidzein-2c was used at 1 µM final concentration in various in vitro assays.
In vivo: N/A

Reference:

1. Amy L, et al. Design, Synthesis, and Osteogenic Activity of Daidzein Analogs on Human Mesenchymal Stem Cells. (2014) ACS Med. Chem. Lett., In press.

Products are for research use only. Not for human use.

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