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 ML324,JMJD2HistoneDemethylaseInhibitor M60183-2s|产品详情|进口橙子视频旧款采购网




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    上海橙子视频app安卓下载生物科技公司
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    ML324,JMJD2HistoneDemethylaseInhibitor
    品牌:Xcessbio
    货号:M60183-2s
    规格:2mg solid
    货期:

    ML324,JMJD2HistoneDemethylaseInhibitor

    商品详情 参考文献 相关资料
    Product Information
    Molecular Weight: 349.43
    Formula: C21H23N3O2
    Purity: ≥98%
    CAS#: 1222800-79-4
    Solubility: DMSO up to 100 mM
    Chemical Name: N-(3-(dimethylamino)propyl)-4-(8-hydroxyquinolin-6-yl)benzamide
    Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

    Biological Activity:

    ML324 is a potent, selective and cell permeable inhibitor of Jumonji domain-containing protein 2 (JMJD2) histone demethylase with IC50 ~0.92 µM toward JMJD2E. It has excellent in vitro ADME properties, and it could effectively block both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection via inhibition viral IE gene expression. ML324 suppresses the formation of HSV plaques, even at high MOI, and blocks HSV-1 reactivation in a mouse ganglia explant model of latently infected mice.

     

    How to Use: 

    • In vitro: ML324 was used at 10-50 µM in vitro and cellular assays.
    • In vivo: n/a

     

    Reference:

    • 1. Rai G, et al. Discovery of ML324, a JMJD2 demethylase inhibitor with demonstrated antiviral activity. (2012) Probe Reports from the NIH Molecular Libraries Program.
    • 2. Liang Y, et al. Targeting the JMJD2 histone demethylases to epigenetically control herpesvirus infection and reactivation from latency. (2013) Sci Transl Med. 5(167):167ra5.
     
     

     

    Products are for research use only. Not for human use.

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