肾脏近曲小管上皮细胞在肾脏功能中起了关键作用。它们重吸收肾小球滤液中几乎所有的葡萄糖和氨基酸，允许其它无营养价值的物质排放至尿液中。在先天性疾病、新陈代谢疾病以及炎症反应中，该细胞出现于损伤部位附近，可分泌如细胞因子和趋化因子等炎症介质，并可通过产生IL-8影响和直接参与白细胞趋化反应，进而参与急性炎症反应的过程。在炎症、肾移植术后及新月体肾小球肾炎中，该细胞可表达IL-2R α型和**类MHC分子。肾近曲小管上皮细胞的培养为研究管状细胞与肾脏疾病之间的关联提供了一个有用的体外模型。
Sciencell研究实验室的人肾近曲小管上皮细胞是从人的肾中分离得到的，一代冻存，冰冻运输。每管细胞密度*过5×10^5/ml。该细胞可通过细胞因子-18、-19和波形蛋白特异性抗体的免疫荧光进行鉴定。本细胞经检测不含HIV-1、HBV、HCV、支原体、细菌、酵母菌和真菌。如采用ScienCell 实验室特制的培养基，可保证此细胞15倍增殖。
推荐培养基：上皮细胞培养基 (EpiCM, Cat. #4101)
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货号
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4100
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产地
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美国
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缩写
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HRPTEpiC
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规格
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5 x 10^5/1ml
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用途
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科研
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储存
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液氮
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运输
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干冰
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4.) Zhang H, Tasnim F, Ying JY, Zink D. (2009) "The impact of extracellular matrix coatings on the performance of human renal cells applied in bioartificial kidneys."Biomaterials. 30: 2899-911.
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