肺微血管内皮细胞构成半选择性屏障，该屏障对于肺气体交换，调节液体和可溶物在血液与肺间质之间的流动具有重要意义。它还具有代谢功能，可以执行一定的非呼吸功能。在肺损伤中，PMECs是活性氧类的重要靶细胞之一。在肺炎的发生过程中，神经体液介质和氧化剂作用于内皮细胞，使得细胞间隙渗透性增加，蛋白质由血液进入间质。细胞间隙渗透性的增加导致低氧血症，出现**呼吸窘迫综合征和非心源性肺水肿。
人肺微血管内皮细胞提取于人肺组织，细胞提取纯化之后立即冻存。每管含有细胞数>5×105 cells/ml，此细胞通过vWF/Factor VIII 和CD31 (P-CAM)免疫荧光染色验证，经测试不含有HIV-1、HBV、HCV、支原体、细菌、酵母和真菌。细胞可以达到10倍增。
推荐培养基：内皮细胞培养基 (ECM, Cat. #1001)
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货号
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3000
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产地
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美国
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缩写
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HPMEC
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规格
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5 x 10^5 /1ml
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用途
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科研
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储存
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液氮
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运输
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干冰
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