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Anti-ELN Antibody |产品详情|进口橙子视频旧款采购网




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    上海橙子视频app安卓下载生物科技公司
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    Anti-ELN Antibody
    品牌:Antibodies
    货号:
    规格:100µl
    货期:

    Anti-ELN Antibody

    商品详情 参考文献 相关资料
    Name: Anti-ELN Antibody
    See all ELN primary antibodies
    Description: Rabbit polyclonal antibody to ELN
    Specificity: The antibody detects endogenous levels of total ELN protein.
    Applications: WB, IHC
    Reactivity: Human
    Immunogen: Fusion protein corresponding to a region derived from internal residues of human elastin
    Host: Rabbit
    Clonality: Polyclonal
    Conjugate: Unconjugated
    Purification: Antigen affinity purification.
    Concentration: 2.1mg / ml
    Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
    Storage: Store at -20?C
    Function: Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity).
    Tissue Specificity: Expressed within the outer myometrial smooth muscle and throughout the arteriolar tree of uterus (at protein level). Also expressed in the large arteries, lung and skin.
    Involvement in Disease: Cutis laxa, autosomal dominant, 1: A connective tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. Face, hands, feet, joints, and torso may be differentially affected. Additional variable clinical features are gastrointestinal diverticula, hernia, and genital prolapse. Rare manifestations are pulmonary artery stenosis, aortic aneurysm, bronchiectasis, and emphysema.

    Supravalvular aortic stenosis: Congenital narrowing of the ascending aorta which can occur sporadically, as an autosomal dominant condition, or as one component of Williams-Beuren syndrome.
    Sequence Similarities: Belongs to the elastin family.
    Post-Translational Modification: Elastin is formed through the cross-linking of its soluble precursor tropoelastin. Cross-linking is initiated through the action of lysyl oxidase on exposed lysines to form allysine. Subsequent spontaneous condensation reactions with other allysine or unmodified lysine residues result in various bi-, tri-, and tetrafunctional cross-links. The most abundant cross-links in mature elastin fibers are lysinonorleucine, allysine aldol, desmosine, and isodesmosine.
    Cellular locations: Secreted > Extracellular space > Extracellular matrix.

    Extracellular matrix of elastic fibers.
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