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Anti-DOK2 Antibody

品牌：Antibodies

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规格：100µl

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Anti-DOK2 Antibody

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Name:	Anti-DOK2 Antibody See all DOK2 primary antibodies
Description:	Rabbit polyclonal antibody to DOK2
Specificity:	The antibody detects endogenous levels of total DOK2 protein.
Applications:	IHC
Reactivity:	Human
Immunogen:	Synthetic peptide of human DOK2
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification
Concentration:	0.4mg / ml
Formulation:	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage:	Store at -20?C

Function:	DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity).
Tissue Specificity:	Highly expressed in peripheral blood leukocytes, lymph nodes and spleen. Lower expression in thymus, bone marrow and fetal liver.
Sequence Similarities:	Belongs to the DOK family. Type A subfamily.
Post-Translational Modification:	On immunoreceptor stimulation, phosphorylated on C-terminal tyrosine residues. Phosphorylation on Tyr-345 is required for binding to the SH2 domain of NCK. Phosphorylation on both Tyr-271 and Tyr-299 is required for interaction with RASGAP. Phosphorylated on tyrosine residues by TEK/TIE2 (By similarity).
Database Links:	Entrez Gene: 9046?Human Omim: 604997?Human SwissProt: O60496?Human Unigene: 71215?Human
Synonyms:	Docking protein 2 Antibody Docking protein 2 56kDa Antibody DOK 2 Antibody DOK R Antibody DOK2 Antibody DOK2_HUMAN Antibody Downstream of tyrosine kinase 2 Antibody OTTHUMP00000161710 Antibody OTTHUMP00000224923 Antibody p56(dok 2) Antibody p56(dok-2) Antibody p56DOK Antibody p56dok 2 Antibody p56dok2 Antibody
Information:	Target information shown above is from the UniProt Consortium.