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Anti-DOK1 Antibody

品牌：Antibodies

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规格：50µl

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Anti-DOK1 Antibody

商品详情参考文献相关资料

Name:	Anti-DOK1 Antibody See all DOK1 primary antibodies
Description:	Rabbit polyclonal antibody to DOK1.
Applications:	WB, IHC
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human DOK1.
Protein Length:	481
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Function:	DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same on ITGB3.
Tissue Specificity:	Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer.
Sequence Similarities:	Belongs to the DOK family. Type A subfamily.
Post-Translational Modification:	Constitutively tyrosine-phosphorylated. Phosphorylated by TEC (By similarity). Phosphorylated by LYN (By similarity). Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. Phosphorylated on tyrosine residues by SRMS.
Cellular locations:	Cytoplasm. Nucleus.
Database Links:	Entrez Gene: 1796?Human Entrez Gene: 13448?Mouse Entrez Gene: 312477?Rat Omim: 602919?Human SwissProt: Q99704?Human SwissProt: P97465?Mouse SwissProt: Q4QQV2?Rat Unigene: 103854?Human Unigene: 156?Mouse Unigene: 117974?Rat
Synonyms:	Docking protein 1 Antibody Docking protein 1 62kD Antibody DOK 1 Antibody DOK1 Antibody DOK1_HUMAN Antibody Downstream of tyrosine kinase 1 Antibody p62(dok) Antibody P62DOK Antibody pp62 Antibody
Information:	Target information shown above is from the UniProt Consortium.