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Anti-DISC1 Antibody

品牌：Antibodies

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规格：100µl

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Anti-DISC1 Antibody

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Overview

Name:	Anti-DISC1 Antibody See all DISC1 primary antibodies
Description:	Rabbit polyclonal antibody to DISC1
Specificity:	The antibody detects endogenous level of total DISC1 antibody.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	A synthetic peptide of human DISC1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were purified by affinity purification using immunogen.
Concentration:	1.0mg / ml
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C

Target

Function:	Involved in the regulation of multiple aspects of embryonic and *** neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the * dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during *** neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.
Tissue Specificity:	Ubiquitous. Highly expressed in the dentate gyrus of the hippocampus. Also expressed in the temporal and parahippocampal cortices and cells of the white matter.
Involvement in Disease:	Schizophrenia 9: A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
Cellular locations:	Cytoplasm. Cytoplasm > Cytoskeleton. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Cell junction > Synapse > Postsynaptic cell membrane > Postsynaptic density. Colocalizes with NDEL1 in the perinuclear region and the centrosome (By similarity). Localizes to punctate cytoplasmic foci which overlap in part with mitochondria. Colocalizes with PCNT at the centrosome.
Database Links:	Entrez Gene: 27185?Human Entrez Gene: 244667?Mouse Entrez Gene: 307940?Rat Omim: 605210?Human SwissProt: Q9NRI5?Human SwissProt: Q811T9?Mouse SwissProt: Q810H6?Rat Unigene: 13318?Human Unigene: 233504?Mouse Unigene: 214038?Rat
Synonyms:	C1orf136 Antibody DISC1 Antibody DISC1_HUMAN Antibody Disrupted in schizophrenia 1 Antibody Disrupted in schizophrenia 1 protein Antibody KIAA0457 Antibody RP4-730B13.1 Antibody SCZD9 Antibody
Information:	Target information shown above is from the UniProt Consortium.