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Anti-CNOT8 Antibody

品牌：Antibodies

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规格：50µl

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Anti-CNOT8 Antibody

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Name:	Anti-CNOT8 Antibody See all CNOT8 primary antibodies
Description:	Rabbit polyclonal antibody to CNOT8.
Applications:	WB, IHC
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human CNOT8.
Protein Length:	292
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Function:	Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
Sequence Similarities:	Belongs to the CAF1 family.
Cellular locations:	Cytoplasm. Nucleus.
Database Links:	Entrez Gene: 9337?Human Entrez Gene: 363603?Rat Omim: 603731?Human SwissProt: Q9UFF9?Human Unigene: 26703?Human Unigene: 203142?Rat
Synonyms:	CAF 1 Antibody CAF 2 Antibody CAF1 Antibody CAF1 like protein Antibody CAF1-like protein Antibody CAF2 Antibody CALIF Antibody CALIFp Antibody CCR4 associated factor 8 Antibody CCR4 NOT transcription complex subunit 8 Antibody CCR4-associated factor 8 Antibody CCR4-NOT transcription complex subunit 8 Antibody CNOT 8 Antibody CNOT8 Antibody CNOT8_HUMAN Antibody hCAF1 Antibody PGK promoter directed over production Antibody POP 2 Antibody POP2 Antibody
Information:	Target information shown above is from the UniProt Consortium.