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Anti-CD207 Antibody

品牌：Antibodies

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规格：100µl

货期：

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Anti-CD207 Antibody

商品详情参考文献相关资料

Name:	Anti-CD207 Antibody See all CD207 primary antibodies
Description:	Rabbit polyclonal antibody to CD207
Specificity:	The antibody detects endogenous levels of total CD207 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse
Immunogen:	Fusion protein corresponding to a region derived from internal residues of human CD207 molecule, langerin
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1.7mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Function:	Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.
Tissue Specificity:	Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues.
Involvement in Disease:	Birbeck granule deficiency: A condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules, Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.
Cellular locations:	Membrane. Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.