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Anti-Caspase 7 Antibody

品牌：Antibodies

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规格：50µl

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Anti-Caspase 7 Antibody

商品详情参考文献相关资料

Name:	Anti-Caspase 7 Antibody See all Caspase 7 primary antibodies
Description:	Rabbit polyclonal antibody to Caspase 7
Specificity:	Caspase 7 pAb detects endogenous levels of Caspase 7 protein.
Applications:	WB, IHC, ICC, IP
Reactivity:	Human, Mouse
Immunogen:	Recombinant full length Human Caspase 7.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 34 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.

Function:	Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Overexpression promotes programmed cell death.
Tissue Specificity:	Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain.
Sequence Similarities:	Belongs to the peptidase C14A family.
Post-Translational Modification:	Cleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of caspase-3, and vice versa, also occur.
Cellular locations:	Cytoplasm.
Database Links:	Entrez Gene: 840?Human Entrez Gene: 12369?Mouse Omim: 601761?Human SwissProt: P55210?Human SwissProt: P97864?Mouse Unigene: 9216?Human Unigene: 35687?Mouse
Synonyms:	Apoptotic protease Mch-3 Antibody Apoptotic protease MCH3 Antibody CASP-7 Antibody CASP7 Antibody CASP7_HUMAN Antibody Caspase 7 Antibody Caspase 7 apoptosis related cysteine peptidase Antibody Caspase-7 Antibody Caspase-7 subunit p11 Antibody Caspase7 Antibody CMH 1 Antibody CMH-1 Antibody CMH1 Antibody ICE LAP3 Antibody ICE-LAP3 Antibody ICE-like apoptotic protease 3 Antibody LICE2 Antibody MCH3 Antibody
Information:	Target information shown above is from the UniProt Consortium.