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Anti-CA4 Antibody

品牌：Antibodies

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规格：50µl

货期：

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Anti-CA4 Antibody

商品详情参考文献相关资料

Name:	Anti-CA4 Antibody See all CA4 primary antibodies
Description:	Rabbit polyclonal antibody to CA4.
Applications:	WB, IHC
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity:	Human, Mouse
Immunogen:	A synthetic peptide of human CA4.
Protein Length:	312
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Function:	Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid.
Tissue Specificity:	Expressed in the endothelium of the choriocapillaris in eyes (at protein level). Not expressed in the retinal epithelium at detectable levels.
Involvement in Disease:	Retinitis pigmentosa 17: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midpseripheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
Sequence Similarities:	Belongs to the alpha-carbonic anhydrase family.
Cellular locations:	Cell membrane.