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Anti-BRCC36 Antibody

品牌：Antibodies

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规格：100µl

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Anti-BRCC36 Antibody

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Overview

Name:	Anti-BRCC36 Antibody See all BRCC36 primary antibodies
Description:	Rabbit polyclonal antibody to BRCC36
Applications:	E, WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Raised against a 18 amino acid peptide from near the amino terminus of human BRCC36.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Affinity chromatography purified via peptide column
Formulation:	Supplied in PBS containing 0.02% sodium azide.
Storage:	Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target

Function:	Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination.
Sequence Similarities:	Belongs to the peptidase M67A family. BRCC36 subfamily.
Cellular locations:	Nucleus. Cytoplasm. Cytoplasm > Cytoskeleton > Spindle pole. Localizes at sites of DNA damage at double-strand breaks (DSBs). Interaction with ABRAXAS2 retains BRCC3 in the cytoplasm.
Database Links:	Entrez Gene: 79184?Human Entrez Gene: 210766?Mouse Entrez Gene: 316794?Rat Omim: 300617?Human SwissProt: P46736?Human SwissProt: P46737?Mouse SwissProt: B2RYM5?Rat Unigene: 558537?Human Unigene: 226957?Mouse Unigene: 52727?Rat
Synonyms:	BRCA1-A complex subunit BRCC36 Antibody BRCA1/BRCA2 containing complex subunit 3 Antibody BRCA1/BRCA2 containing complex subunit 36 Antibody BRCA1/BRCA2-containing complex subunit 3 Antibody BRCA1/BRCA2-containing complex subunit 36 Antibody Brcc3 Antibody BRCC36 Antibody BRCC3_HUMAN Antibody BRISC complex subunit BRCC36 Antibody C6.1A Antibody Chromosome X open reading frame 53 Antibody CXorf53 Antibody Lys-63-specific deubiquitinase BRCC36 Antibody OTTHUMP00000061450 Antibody
Information:	Target information shown above is from the UniProt Consortium.