Anti-PAK1 / 2 / 3 (Ab-423 / 402 / 421) Antibody |产品详情|进口橙子视频旧款采购网

您好，欢迎来到橙子视频app安卓下载生物网站！请登录注册

我的订单 | 联系橙子视频app安卓下载 | 在线客服QQ：3012681483 | 客服电话：400-968-7988 | 工作时间：08:30-17:30

主营产品： ELISA91橙子视频、抗体、补体血清、兔补体、干扰素、小鼠测温仪、进口橙子视频旧款、Quidel代理、Swant代理、PBL Assay Science代理

网站首页产品中心代理品牌新闻资讯资源中心关于橙子视频app安卓下载

所在位置：首页 > 产品中心 > Antibodies > Antibodies产品

Anti-PAK1 / 2 / 3 (Ab-423 / 402 / 421) Antibody

订购信息

上海橙子视频app安卓下载生物科技公司

Tel:400-968-7988 021-33779008

Anti-PAK1 / 2 / 3 (Ab-423 / 402 / 421) Antibody

品牌：Antibodies

货号：

规格：50µl

货期：

应用：

咨询客服

立即购买加入购物车

Anti-PAK1 / 2 / 3 (Ab-423 / 402 / 421) Antibody

商品详情参考文献相关资料

Target

Function:	Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. The ATG12-ATG5 conjugate also negatively regulates the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
Tissue Specificity:	Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells.
Sequence Similarities:	Belongs to the ATG5 family.
Post-Translational Modification:	Conjugated to ATG12; which is essential for autophagy, but is not required for association with isolation membrane.
Cellular locations:	Cytoplasm. Preautophagosomal structure membrane. Colocalizes with nonmuscle actin. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme.
Database Links:	Entrez Gene: 9474 Human Entrez Gene: 11793 Mouse Entrez Gene: 365601 Rat Omim: 604261 Human SwissProt: Q9H1Y0 Human SwissProt: Q99J83 Mouse SwissProt: Q3MQ06 Rat Unigene: 486063 Human Unigene: 22264 Mouse Unigene: 98385 Rat
Synonyms:	APG 5 Antibody APG 5L Antibody APG5 Antibody APG5 autophagy 5 like Antibody APG5 like Antibody APG5-like Antibody APG5L Antibody APG5L/ATG5 Antibody Apoptosis specific protein Antibody Apoptosis-specific protein Antibody ASP Antibody ATG 5 Antibody Atg5 Antibody ATG5 autophagy related 5 homolog Antibody ATG5_HUMAN Antibody Autophagy protein 5 Antibody Autophagy related 5 Antibody hAPG5 Antibody Homolog of S Cerevisiae autophagy 5 Antibody OTTHUMP00000040507 Antibody
Information:	Target information shown above is from the UniProt Consortium.