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Anti-NOL3 Antibody

品牌：Antibodies

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规格：50µl

货期：

应用：

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Anti-NOL3 Antibody

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Overview

Name:	Anti-NOL3 Antibody See all NOL3 primary antibodies
Description:	Rabbit polyclonal antibody to NOL3.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:10 - 1:100.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human NOL3.
Protein Length:	219 (208)
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Isoform 1: May be involved in RNA splicing.
Tissue Specificity:	Highly expressed in heart and skeletal muscle. Detected at low levels in placenta, liver, kidney and pancreas.
Involvement in Disease:	Myoclonus, familial cortical: An autosomal dominant neurologic condition characterized by ***** onset of cortical myoclonus manifest as involuntary jerks or movements affecting the face and limbs. Affected individuals can also experience falls without seizure activity or loss of consciousness.
Post-Translational Modification:	Phosphorylation at Thr-149 is required for its antiapoptotic effect by blocking death-inducing signaling complex death-inducing signaling complex (DISC) activity through the control of interaction with CASP8. Phosphorylation at Thr-149 results in translocations to mithochondria and this translocations enables the binding to CASP8. Dephosphorylated at Thr-149 by calcineurin; doesn't inhibit the association between FADD and CASP8 and the consequent apoptosis.
Cellular locations:	Nucleus > Nucleolus. The SR-rich C-terminus mediates nuclear localization.
Database Links:	Entrez Gene: 8996?Human Entrez Gene: 78688?Mouse Entrez Gene: 85383?Rat Omim: 605235?Human SwissProt: O60936?Human SwissProt: Q9D1X0?Mouse SwissProt: Q62881?Rat Unigene: 513667?Human Unigene: 204876?Mouse Unigene: 475715?Mouse Unigene: 86956?Rat
Synonyms:	Apoptosis repressor with CARD Antibody ARC Antibody Muscle enriched cytoplasmic protein Antibody Muscle-enriched cytoplasmic protein Antibody MYC Antibody MYP Antibody Nol3 Antibody NOL3_HUMAN Antibody NOP Antibody Nop30 Antibody Nucleolar protein 3 Antibody Nucleolar protein 3 (apoptosis repressor with CARD domain) Antibody Nucleolar protein of 30 kDa Antibody
Information:	Target information shown above is from the UniProt Consortium.