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Anti-ARF1 Antibody

品牌：Antibodies

货号：

规格：100µg

货期：

应用：

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Anti-ARF1 Antibody

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Overview

Name:	Anti-ARF1 Antibody See all ARF1 primary antibodies
Description:	Goat polyclonal antibody to ARF1.
Applications:	ELISA, WB
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human ARF1 (C terminal).
Sequence:	C-EGLDWLSNQLRNQK
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 µg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).
Sequence Similarities:	Belongs to the small GTPase superfamily. Arf family.
Post-Translational Modification:	Demyristoylated by S.flexneri cysteine protease IpaJ which cleaves the peptide bond between N-myristoylated Gly-2 and Asn-3.
Cellular locations:	Golgi apparatus. Cytoplasm > Perinuclear region. Cell junction > Synapse > Synaptosome. Cell junction > Synapse > Postsynaptic cell membrane > Postsynaptic density. Membrane.
Database Links:	Entrez Gene: 375 Human Omim: 103180 Human SwissProt: P84077 Human Unigene: 286221 Human
Synonyms:	ADP Ribosylation Factor 1 Antibody ADP-ribosylation factor 1 Antibody ARF 1 Antibody ARF1 Antibody ARF1_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.