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Anti-Blood Group Lewis b Antibody

品牌：Antibodies

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规格：100µg

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Anti-Blood Group Lewis b Antibody

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Name:	Anti-Blood Group Lewis b Antibody See all Blood Group Lewis b primary antibodies
Description:	Mouse monoclonal (2-25LE) antibody to Blood Group Lewis b.
Specificity:	The antibody 2-25LE reacts with Lewis^b blood group antigen, a carbohydrate determinant carried on both glycolipids and glycoproteins, detected on erythrocytes, certain epithelial cells, and in secretions of certain individuals.
Applications:	IHC-P, WB, ELISA
Reactivity:	Human
Immunogen:	Mucin isolated by size exclusion chromatography from an ovarian cyst fluid (pure endocervical type according to the Fenoglio′s classification).
Host:	Mouse
Clonality:	Monoclonal
Clone:	2-25LE
Isotype:	IgG1
Conjugate:	Unconjugated
Purification:	Protein A chromatography.
Concentration:	1 mg/ml
Purity:	> 95% (by SDS-PAGE)
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.4, with 15mM Sodium Azide.
Storage:	Store at 2-8°C.

Function:	Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by the mucocilary system.
Tissue Specificity:	Highly expressed in surface mucosal cells of respiratory tract and stomach epithelia. Overexpressed in a number of carcinomas. Also expressed in Barrett's esophagus epithelium and in the proximal duodenum.
Post-Translational Modification:	C-, O- and N-glycosylated. O-glycosylated on the Thr-/Ser-rich tandem repeats. C-mannosylation in the Cys-rich subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum during biosesynthesis.
Cellular locations:	Secreted.
Database Links:	Entrez Gene: 4586?Human SwissProt: P98088?Human Unigene: 534332?Human Unigene: 558950?Human Unigene: 721515?Human
Synonyms:	Blood Group Lewis b Antibody gastric mucin Antibody leB Antibody lewis antigen system Antibody lewis b Antibody lewis B blood group antigen Antibody lewisb Antibody major airway glycoprotein Antibody MUC5 Antibody mucin 5, subtypes A and C, tracheobronchial/gastric Antibody mucin 5AC, oligomeric mucus/gel-forming Antibody mucin 5AC, oligomeric mucus/gel-forming pseudogene Antibody mucin-5 subtype AC, tracheobronchial Antibody TBM Antibody tracheobronchial mucin Antibody
Information:	Target information shown above is from the UniProt Consortium.