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Anti-c-Myc Antibody

品牌：Antibodies

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规格：100µg

货期：

应用：

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Anti-c-Myc Antibody

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Overview

Name:	Anti-c-Myc Antibody See all c-Myc primary antibodies
Description:	Mouse monoclonal (9E10) antibody to c-Myc.
Specificity:	The antibody 9E10 may be used to detect the c-Myc tag.
Applications:	FC, IP, WB, IHC-P
Reactivity:	Human
Immunogen:	Synthetic peptide sequence (AEEQKLISEEDLL) corresponding to the C-terminal region of human c-Myc.
Host:	Mouse
Clonality:	Monoclonal
Clone:	9E10
Isotype:	IgG1
Conjugate:	Unconjugated
Purification:	Protein A chromatography.
Concentration:	1 mg/ml
Purity:	> 95% (by SDS-PAGE)
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.4, with 15mM Sodium Azide.
Storage:	Store at 2-8°C.

Target

Function:	Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.
Involvement in Disease:	Burkitt lymphoma: A form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass.
Post-Translational Modification:	Phosphorylated by PRKDC. Phosphorylation at Ser-329 by PIM2 leads to the stabilization of MYC (By similarity). Phosphorylation at Ser-62 by CDK2 prevents Ras-induced senescence. Phosphorylated at Ser-62 by DYRK2; this primes the protein for subsequent phosphorylation by GSK3B at Thr-58. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome.
Cellular locations:	Nucleus > Nucleoplasm. Nucleus > Nucleolus.
Biotechnological Use:	POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes.
Database Links:	Entrez Gene: 4609?Human Omim: 190080?Human SwissProt: P01106?Human Unigene: 202453?Human
Synonyms:	AU016757 Antibody Avian myelocytomatosis viral oncogene homolog Antibody bHLHe39 Antibody c Myc Antibody c-Myc Antibody Class E basic helix-loop-helix protein 39 Antibody MRTL Antibody Myc Antibody Myc Epitope Tag Antibody Myc protein Antibody Myc proto oncogene protein Antibody Myc proto-oncogene protein Antibody myc related translation/localization regulatory factor Antibody myc-related translation/localization regulatory factor Antibody Myc2 Antibody MYCC Antibody MYC_HUMAN Antibody Myelocytomatosis oncogene Antibody Niard Antibody Nird Antibody oncogene c-Myc Antibody Oncogene Myc Antibody OTTHUMP00000158589 Antibody Proto-oncogene c-Myc Antibody Protooncogene homologous to myelocytomatosis virus Antibody RNCMYC Antibody Transcription factor p64 Antibody Transcriptional regulator Myc-A Antibody v myc avian myelocytomatosis viral oncogene homolog Antibody v myc myelocytomatosis viral oncogene homolog Antibody V-Myc avian myelocytomatosis viral oncogene homolog Antibody v-myc myelocytomatosis viral oncogene homolog (avian) Antibody
Information:	Target information shown above is from the UniProt Consortium.