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 Anti-NGAL (human) ABS 062-14 ABS 062-14|产品详情|进口橙子视频旧款采购网




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    Anti-NGAL (human) ABS 062-14
    品牌：
    货号：ABS 062-14
    规格：200 µg
    货期：

    Anti-NGAL (human)
    商品详情 参考文献 相关资料
    Cat. No.
    ABS 062-14
    Product name
    Anti-NGAL (human)
    Description

    Mouse monoclonal antibody

    Specificity

    ABS 062-14 is specific for human NGAL (neutrophil gelatinase-associated lipocalin)

    Immunogen

    Human recombinant NGAL coupled to carrier 

    Application
    ELISA
    Species reactivity (positive)
    Human
    Species reactivity (negative)
    Not determined
    Subclass

    IgG2a/k

    Gene ID
    3934
    Clone number
    14
    Epitope

    Differs from those of HYB 211-01, the ABS 038 series of antibodies and ABS 062-33.

    Content

    Available in 200 µL and 1 mL size.1 mg/mL +/- 15%. See Certificate of Analysis for details.

    Purification
    Protein-A purified
    Form
    Liquid
    Solvent
    0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide
    Storage
    4-8ºC without exposure to light. No precautions necessary during handling.
    Target

    Neutrophil gelatinase-associated lipocalin (NGAL; also called lipocalin 2, siderocalin and neutrophil lipocalin) is a member of the lipocalin family of proteins which bind and transport small lipophilic molecules. NGAL is released by activated neutrophils and occurs as 25-kDa glycosylated single protein chain monomers, which form dimers and small amounts of higher oligomers, as well as complexes with matrix metalloproteinase 9 (MMP-9; gelatinase B). Low level expression of NGAL in a variety of epithelia may be increased in inflammation or cancers. Expression of NGAL in the kidney is dramatically increased by acute kidney injury.

    Application 1
    ELISA
    ABS 062-14 binds human NGAL coated onto a solid phase. 
    ABS 062-14 forms a sandwich pair with HYB 211-01, ABS 038-04, -14, -15, -23, -26 and ABS 062-33 for measuring human NGAL.
    When ABS 062-14 is used as biotinylated detection antibody with ABS 062-33 as capture antibody, the assay is specific for NGAL monomer, cross-reacting <1% with NGAL homodimer.
     
    The calibration curve of a sandwich assay for monomer human NGAL using ABS 062-33 as the capture antibody and ABS 062-14B as the biotinylated detection antibody (1).

    1. Bangert et al (2013) The Monomer is the Major Form of NGAL in Urine and Plasma in Severe Sepsis J Am Soc Nephrol 24: 368A

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